Ibrahim-Verbaas, C A; Bressler, J; Debette, S; Schuur, M; Smith, A V; Bis, J C; Davies, G; Trompet, S; Smith, J A; Wolf, C; Chibnik, L B; Yu, L; De Stefano, A L; Beiser, A; Garcia, M; Rotter, J I; Nöthen, M M; Hofman, A; Slagboom, P E; Westendorp, R G J; Buckley, B M; Wright, A F; Räikkönen, K; Wolf, P A; Uitterlinden, A G; Psaty, B M; Grabe, H J; Bandinelli, S; Chasman, D I; Lambert, J-C; Porteous, D J; Price, J F; Wilson, J F; Sachdev, P S; Ferrucci, L; Attia, J R; Rudan, I; Hayward, C; Liu, Y; Cichon, S; Franke, L; Schmidt, H; Ding, J; de Craen, A J M; Fornage, M; Bennett, D A; Deary, I J; Schmidt, C O; Vitart, V; Ikram, M A; Launer, L J; Fitzpatrick, A L; Seshadri, S; van Duijn, C M; Mosley, T H; Kirin, M; Petrovic, K; Polasek, O; Mather, K A; Zgaga, L; Fawns-Ritchie, C; Hoffmann, P; Karjalainen, J; Lahti, J; Llewellyn, D J; Chouraki, V; Sun, Q; Resnick, S M; Rose, L M; Oldmeadow, C; Stewart, M; Smith, B H; Gudnason, V; Au, R; Yang, Q; Mirza, S S; Jukema, J W; de Jager, P L; Harris, T B; Liewald, D C; Amin, N; Coker, L H; Stegle, O; Lopez, O L; Fehrmann, R S N; Schmidt, R; Teumer, A; Ford, I; Karbalai, N; Becker, J T; Jonsdottir, M K; Herms, S; Nalls, M; Zhao, W; Turner, S T; Yaffe, K; Lohman, K; van Swieten, J C; Kardia, S L R; Pilling, L C; Knopman, D S; Meeks, W M; Heiss, G; Holliday, E G; Schofield, P W; Tanaka, T; Stott, D J; Wang, J; Ridker, P; Gow, A J; Eiriksdottir, G; Pattie, A; Starr, J M; Hocking, L J; Armstrong, N J; Mc Lachlan, S; Shulman, J M; Scott, R J; Kochan, N A; Palotie, A; Hsieh, Y-C; Eriksson, J G; Penman, A; Gottesman, R F; Oostra, B A; Grodstein, FTo identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium.
Neuropsychological testing was available for 5429-32 070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time of cognitive testing from 20 cohorts in the discovery phase.
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