The gang gets involved in the world of fashion design after Dee gets jealous of her former high-school best friend (Judy Greer), who is now a successful boutique owner.Meanwhile, Frank starts up his old sweatshop business and coaches Mac on how to run one.
First, the Mc Poyles get revenge on the gang for revealing their false molestation charge (from season one's finale "Charlie Got Molested") and inadvertently shooting their brother Doyle (from this season's "The Gang Gets Invincible") after he was invited to the Eagles' training camp by taking all of them hostage in their own bar.
Finally, Charlie's illiteracy screws over the gang when he accidentally puts the bar up as a prize for a dance marathon, and all the enemies made throughout the course of the series enter the contest so they can take the bar away from the gang.
When the Philadelphia Eagles hold open try-outs à la the movie Invincible, Mac, Dennis, and Dee use the event for their own personal competition.
Meanwhile, Frank and Charlie go to a tailgate party, where Frank trips on LSD and make things worse between them and the Mc Poyle family (from "Charlie Got Molested" and "Charlie Goes America All Over Everybody's Ass").
The gang then hatches several schemes to become famous: Mac, Frank, and Charlie try to be viral video stars by covering the local news while Dennis and Dee seek fame as spoiled, drug-addled club hoppers.