It was then announced that Elson was the new face of British department store John Lewis for autumn/winter 2008/09.
In the autumn of 2009 she appeared on billboards internationally for H&M. John announced that Elson would be replacing Angelina Jolie as the new face of their company. She appears in the autumn/winter 2010/11 ad campaign of Louis Vuitton along with Natalia Vodianova and Christy Turlington, as well as the Trussardi 1911 spring 2011 campaign.
They announced their amicable separation after six years of marriage in 2011, but decided to celebrate the time they had shared by throwing a 'divorce party' for friends and family in Nashville, Tennessee.
She was shot by Mert and Marcus for Roberto Cavalli's autumn 2011 campaign.
Karen appears in the Steven Meisel autumn 2011 Lanvin campaign.
They split 11 months later, but soon reconciled, only to call it quits for good in 2015.
Meanwhile, Karen was previously married to rocker Jack White and they are parents to kids Scarlett and Henry Lee.
She has worked with most of the world's major fashion photographers and fashion designers, including Arthur Elgort, Bruce Weber, Mario Testino, Peter Lindbergh, Mert and Marcus, Steven Klein, Patrick Demarchelier, Steven Meisel, Ellen Von Unwerth.