In January 2012, Annable was confirmed to star as the male protagonist on the ABC supernatural drama series 666 Park Avenue alongside Rachael Taylor, Vanessa Williams and Robert Buckley, which was picked up for a first season of 13 episodes in May.
666 Park Avenue returned to ABC in June 2013 to burn off its remaining episodes.
There, he became involved with the student-run TV station, Plattsburgh State Television (PSTV), working both on production behind the scenes and on the air as well.
He hosted many shows at PSTV, including Late Night with Dave Annable, Cardinal Sports, and The Roommate Game.
He married Odette Yustman on October 10, 2010, who was also a love interest of Annable's character on the final season of Brothers & Sisters.